Triethylamine → HCID 69002932, compound

Participants

Reaction Steps

In a similar manner to Example 29, a free base of Compound 247 was synthesized from 3-methylthiophene-2-carboxylic acid (0.13 g, 0.94 mmol), thionyl chloride (0.10 mL, 1.4 mmol), DMF (few drops), (E)-2-[2-(1H-indazol-3-yl)vinyl]-5-(morpholin-4-yl)phenylamine (0.10 g, 0.31 mmol) obtained in Step 2 of Example 246 and triethylamine (0.13 mL, 0.94 mmol). Further, said free base was added with 1 mol/L hydrogen chloride-ethanol solution (2.0 mL), stirred for 1 hour and then the reaction mixture was concentrated. The residue was triturated in acetone to obtain Compound 247 (61 mg, 44%).

Provenance & Evidence