反应详情

温度

100 °C

4-Fluoro-2-nitrobenzaldehyde (0.20 g, 1.2 mmol), 1-hydroxyethylpiperazin (0.80 mL, 6.5 mmol) and DMSO (3.5 mL) were added and stirred at 100° C. for 1.5 hours. The reaction mixture was added with water and was washed with hexane/ethyl acetate=4/1 to remove impurities. After removing impurities, the reaction mixture was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate. Then, the solvent was evaporated under reduced pressure to obtain 4-[4-(2-hydroxyethyl)piperazin-1-yl]-2-nitrobenzaldehyde (0.34 g, 100%).

1. washwas washed with hexane/ethyl acetate=4/1
2. customto remove impurities
3. customAfter removing impurities
4. extractionthe reaction mixture was extracted with ethyl acetate
5. washthe organic layer was washed with water and saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customThen, the solvent was evaporated under reduced pressure