Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Fluoro-2-nitrobenzaldehyde | HCID 76226 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 71627659 | HCID 71627659 | 169% |
Reaction Steps
A solution of 4-fluoro-2-nitrobenzaldehyde (0.50 g, 3.0 mmol) in DMSO (5.0 mL) was added with 1-(tert-butoxycarbonyl)piperazine (1.7 g, 8.9 mmol), followed by stirring at 80° C. for 5 hours. The reaction mixture was added with water and the precipitated solid was collected by filtration to obtain 4-(4-formyl-3-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester (1.7 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07605272B2 |
|---|
| Source dataset | uspto-grants-2009_10 |
|---|
| ORD ID | ord-04c2eac0cd454fcca08dd3a8ec0f34fd |
|---|
| Source note | uspto-grants-2009_10 |
|---|
