Dimethyl Sulfoxide → HCID 20026310, compound

Participants

Reaction Conditions

Reaction Steps

4-Fluoro-2-nitrobenzaldehyde (0.20 g, 1.2 mmol), methoxyethanol (0.28 mL, 3.6 mmol) and DMSO (2.0 mL) were added and stirred at 60° C. for 1.5 hours. The reaction mixture was added with water and was washed with hexane/ethyl acetate=4/1 to remove impurities. After removing impurities, the reaction mixture was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate. Then, the solvent was evaporated under reduced pressure. The filtrate was purified by silica gel column chromatography (hexane/ethyl acetate=4/1 to 1/1) and concentrated to obtain 4-(2-methoxyethoxy)-2-nitrobenzaldehyde (28 mg, 10%).

Provenance & Evidence