Dimethylformamide → HCID 69000935, compound

Participants

Reaction Steps

In a similar manner to Example 29, 5-(methylsulfonyl)thiophene-2-carboxylic acid (97 mg, 0.47 mmol) was treated with thionyl chloride (53 μL, 0.72 mmol), DMF (5.0 μL, 0.085 mmol) and dichloromethane (2.0 mL), followed by reacting with Compound 2 (0.10 g, 0.43 mmol), triethylamine (60 μL, 1.1 mmol) and THF (2.0 mL) to obtain Compound 354 (58 mg, 32%).

Provenance & Evidence