Ethenesulfonyl chloride, 2-phenyl- → HCID 10153539, compound

HRID 1821461Notes

Reaction equation

HRID 1821461 reaction equation
[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38]S(CC1C=CC=CC=1)(=O)=O)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:49]1([CH:55]=[CH:56][S:57](Cl)(=[O:59])=[O:58])[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1>>[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38][S:57](/[CH:56]=[CH:55]/[C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)(=[O:59])=[O:58])([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 107500Ethenesulfonyl chloride, 2-phenyl-HCID 9874688HCID 9874688, compound

Product 1

HCID 10153539HCID 10153539, compoundYield 66%

Procedure

To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) was added 2-phenyl-ethenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 66% yield.

Sources & evidence

ORD record
ord-5c32f9616fd547a693eca1ebdf3cd19a
Source dataset
uspto-grants-2009_10
Patent number
US07605156B2

Reaction notes

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