(2,4-Dichlorophenyl)methanesulfonyl chloride → HCID 12113885, compound

HRID 1821468Notes

Reaction equation

HRID 1821468 reaction equation
[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38]S(CC1C=CC=CC=1)(=O)=O)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:49][C:50]1[CH:55]=[C:54]([Cl:56])[CH:53]=[CH:52][C:51]=1[CH2:57][S:58](Cl)(=[O:60])=[O:59]>>[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38][S:58]([CH2:57][C:51]1[CH:52]=[CH:53][C:54]([Cl:56])=[CH:55][C:50]=1[Cl:49])(=[O:60])=[O:59])([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 594471(2,4-Dichlorophenyl)methanesulfonyl chlorideHCID 9874688HCID 9874688, compound

Product 1

HCID 12113885HCID 12113885, compoundYield 98%

Procedure

To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) was added [(2,4-dichlorophenyl)-methyl]sulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 98% yield.

Sources & evidence

ORD record
ord-9fc5cf954fba499b92c615920a2dc66c
Source dataset
uspto-grants-2009_10
Patent number
US07605156B2

Reaction notes

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