HCID 9874688, compound → HCID 10312695, compound

HRID 1821469Notes

Reaction equation

HRID 1821469 reaction equation
[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38]S(CC1C=CC=CC=1)(=O)=O)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:49][C:50]1[CH:55]=[CH:54][C:53]([CH2:56][S:57](Cl)(=[O:59])=[O:58])=[C:52]([N+:61]([O-:63])=[O:62])[CH:51]=1>>[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38][S:57]([CH2:56][C:53]1[CH:54]=[CH:55][C:50]([Cl:49])=[CH:51][C:52]=1[N+:61]([O-:63])=[O:62])(=[O:59])=[O:58])([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 9874688HCID 9874688, compoundHCID 62100059HCID 62100059, compound

Product 1

HCID 10312695HCID 10312695, compoundYield 74%

Procedure

To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) was added (4-chloro-2-nitro-phenyl)-methanesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 74% yield.

Sources & evidence

ORD record
ord-cfe02e1fb1f44361adf050c028162142
Source dataset
uspto-grants-2009_10
Patent number
US07605156B2

Reaction notes

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