HCID 9874688, compound → HCID 10175768, compound

HRID 1821473Notes

Reaction equation

[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38][S:39]([CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)(=[O:41])=[O:40])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:49](C1C=CC(CS(Cl)(=O)=O)=CC=1)(=[O:52])(=[O:51])[NH2:50]>>[NH2:50][S:49]([C:46]1[CH:45]=[CH:44][C:43]([CH2:42][S:39]([NH:38][CH2:37][CH2:36][C:15]2[N:14]([CH:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:22]3[C:17]([C:16]=2[CH2:24][CH2:25][O:26][C:27]2[CH:28]=[CH:29][C:30]([C:31]([OH:33])=[O:32])=[CH:34][CH:35]=2)=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=3)(=[O:41])=[O:40])=[CH:48][CH:47]=1)(=[O:52])=[O:51]

Participants

Reactant 2

HCID 9874688HCID 9874688, compound

HCID 21962486HCID 21962486, compound

Product 1

HCID 10175768HCID 10175768, compound

Procedure

The title compound was prepared from 4-{2-[2-(2-amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester (Step 6, Example 1) and (4-Sulfamoyl-phenyl)-methanesulfonyl chloride according to Example 1 Step 7.

Sources & evidence

ORD record: ord-9e2d195541ee4d36bfd8e9856e830c3e
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07605156B2

Reaction notes

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