Phenylmethanesulfonyl chloride → HCID 22665538, compound

HRID 1821501Notes

Reaction equation

C[O:2][C:3](=[O:39])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][C:13]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=3)[N:15]([CH:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:14]=2[CH2:36][CH2:37][NH2:38])=[CH:6][CH:5]=1.[C:40]1([CH2:46][S:47](Cl)(=[O:49])=[O:48])[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>>[CH:23]([N:15]1[C:16]2[C:21](=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[C:13]([CH2:12][CH2:11][NH:10][C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:2])=[O:39])=[CH:9][CH:8]=2)=[C:14]1[CH2:36][CH2:37][NH:38][S:47]([CH2:46][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)(=[O:49])=[O:48])([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

Reactant 2

HCID 74740Phenylmethanesulfonyl chloride

HCID 20598524HCID 20598524, compound

Product 1

HCID 22665538HCID 22665538, compoundYield 72%

Procedure

The intermediate from step 12 was treated with α-toluenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 72% yield.

Sources & evidence

ORD record: ord-6e2606b94b944774a6580e31f1b5bdf8
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07605156B2

Reaction notes

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