(3,4-Dichlorophenyl)methanesulfonyl chloride → 4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic Acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(3,4-Dichlorophenyl)methanesulfonyl chloride	HCID 2794622	—
Edukt	4-({2-[2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethyl}methyl-amino)-benzoic acid methyl ester	HCID 20598525	—
Produkt	4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic Acid	HCID 21962384	87%

Reaktionsschritte

The intermediate from Example 147 step 7 was treated with 3,4-dichlorophenylmethanesulfonylchloride according to the procedure in Example 87 step 2 to generate the desired product in 87% yield.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07605156B2
Quelldatensatz	uspto-grants-2009_10
ORD ID	ord-0e302c1a91324276bd1b26c71dcedd20
Quellennotiz	uspto-grants-2009_10