HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methylbenzene-1-sulfonyl chloride → 4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methylbenzene-1-sulfonyl chloride | HCID 15725370 | — |
| Reactant | 4-({2-[2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethyl}methyl-amino)-benzoic acid methyl ester | HCID 20598525 | — |
| Product | 4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic acid | HCID 21962385 | 96% |
Reaction Steps
The intermediate from Example 147 step 7 was treated with 2-chloro-6-methyl-benzenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 96% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605156B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-9852b17bf570462fac7afa972bdac4ea |
| Source note | uspto-grants-2009_10 |