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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1821559Generated: November 4, 2026

N-Carbobenzoxy-L-valine → (S)-Methyl 1-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoyl)pyrrolidine-2-carboxylate

https://huagongshe.com/reaction/1821559

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Carbobenzoxy-L-valineHCID 726987—
ReactantMethyl L-prolinateHCID 853477—
Product(S)-Methyl 1-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoyl)pyrrolidine-2-carboxylateHCID 14032133—

Reaction Steps

Z-Val-OH (3.5 g, 13.9 mmol) and H-Pro-OMe*HCl (2.14 g, 13.9 mmol) were treated in the same manner as above for 1, to give 3 as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07608577B2
Source datasetuspto-grants-2009_10
ORD IDord-89169db16151430b8337a1288128f478
Source noteuspto-grants-2009_10