HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Z-Val-Pro-Val-Pro-CH2-Cl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | Z-Val-Pro-Val-Pro-OH | HCID 131727672 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Z-Val-Pro-Val-Pro-CH2-Cl | HCID 131727671 | — |
Reaction Steps
10 (1.1 g, 2.01 mmol) was treated as described for 13 using CAIBE (0.263 ml, 2.01 mmol), NMM (0.223 ml, 2.02 mmol), diazomethane (10 mmol in 13.3 ml ether) and 5 ml of HCl in dioxane (7.6M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608577B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-423cddb29ec3498a9ef654a0fc898dce |
| Source note | uspto-grants-2009_10 |