Z-Val-Pro-Val-Pro-CH2-Cl → Z-Val-Pro-Val-Pro-CH3

HRID 1821564Notes

Reaction equation

HRID 1821564 reaction equation
[NH:1]([C:31]([O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:32])[C@H:2]([C:6]([N:8]1[CH2:30][CH2:29][CH2:28][C@H:9]1[C:10]([NH:12][C@H:13]([C:17]([N:19]1[CH2:27][CH2:26][CH2:25][C@H:20]1[C:21]([CH2:23]Cl)=[O:22])=[O:18])[CH:14]([CH3:16])[CH3:15])=[O:11])=[O:7])[CH:3]([CH3:5])[CH3:4]>[Zn]>[NH:1]([C:31]([O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:32])[C@H:2]([C:6]([N:8]1[CH2:30][CH2:29][CH2:28][C@H:9]1[C:10]([NH:12][C@H:13]([C:17]([N:19]1[CH2:27][CH2:26][CH2:25][C@H:20]1[C:21]([CH3:23])=[O:22])=[O:18])[CH:14]([CH3:15])[CH3:16])=[O:11])=[O:7])[CH:3]([CH3:4])[CH3:5]

Participants

3

Reactant 1

HCID 131727671Z-Val-Pro-Val-Pro-CH2-Cl

Product 1

HCID 131727677Z-Val-Pro-Val-Pro-CH3

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

15 (1.1 g, 1.91 mmol) was treated as described for 18 using acidic acid (5.3 ml) and zinc (1.31 g).

Sources & evidence

ORD record
ord-50ba686dd4b64b1fbeb270ff3ebe1b0f
Source dataset
uspto-grants-2009_10
Patent number
US07608577B2

Reaction notes

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