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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1821574Generated: October 25, 2026

1-Hydroxybenzotriazole → 2-[(Benzothiazol-2-yl)hydroxymethyl]-1-{N-[N-(tertbutyloxycarbonyl)-(L)-Alanyl]-(L)-Valinyl}-(2S)-pyrrolidine

https://huagongshe.com/reaction/1821574

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-HydroxybenzotriazoleHCID 75771—
ReactantL-Valine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-HCID 11460416—
Reactant2-[(Benzothiazol-2-yl)hydroxymethyl]-(2s)-pyrrolidine hydrochlorideHCID 69033602—
Product2-[(Benzothiazol-2-yl)hydroxymethyl]-1-{N-[N-(tertbutyloxycarbonyl)-(L)-Alanyl]-(L)-Valinyl}-(2S)-pyrrolidineHCID 69031852—

Reaction Steps

36 (0.43 g, 1.23 mmol), HOBt (0.183 g, 1.35 mmol), WSCD (0.259 g, 1.35 mmol), Boc-Ala-Val-OH (0.35 g, 1.23 mmol), TEA (0.172 ml, 1.54 mmol)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07608577B2
Source datasetuspto-grants-2009_10
ORD IDord-4c40ec61c45443ee95f43fb2c4a33fe5
Source noteuspto-grants-2009_10