HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 1-Chloro-6-methoxy-3-methylisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-Methoxy-3-methylisoquinolin-1(2H)-one | HCID 12327060 | — |
| Product | 1-Chloro-6-methoxy-3-methylisoquinoline | HCID 57893095 | — |
Reaction Steps
Isoquinoline-1-one 43 was dissolved in POCl3 (2.5 mL) and heated at reflux for 1h. The excess POCl3 was removed in vacuo and the residue was dissolved in CHCl3. The resulting solution was washed with 1N aq. NaOH, water and saturated ag. NaCl. Evaporation of the solvent gave crude 44 which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608592B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-691bfe019da5468c974cab34905ed9b7 |
| Source note | uspto-grants-2009_10 |