4,6-dichloro-N-phenyl-1,3,5-triazin-2-amine → HCID 9923909, compound

HRID 1821632Notes

Reaction equation

HRID 1821632 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[CH2:22][CH2:21][CH2:20]2>>[Cl:1][C:2]1[N:7]=[C:6]([NH:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[CH2:22][CH2:21][CH2:20]3)[N:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1

Participants

3

Reactant 2

HCID 167664,6-dichloro-N-phenyl-1,3,5-triazin-2-amineHCID 90496Indan-5-amine

Product 1

HCID 9923909HCID 9923909, compoundYield 37%

Procedure

The reaction of 4,6-dichloro-N-phenyl-[1,3,5]triazine-2-amine with 5-aminoindan using the method described for the synthesis of CT-32028 provided CT-32099 (36 mg, 37% yield). 1H NMR (d6-DMSO) δ 10.15-10.28 (m, 2H), 7.56-7.72 (m, 3H), 7.05-7.39 (m, 5H), 2.75-90 (m, 4H), 1.94-2.09 (m, 2H).

Workup

  1. customdescribed for the synthesis of
  2. customCT-32028 provided

Sources & evidence

ORD record
ord-a6b494dd98004fc4aec5ee8336997f8c
Source dataset
uspto-grants-2009_10
Patent number
US07608620B2

Reaction notes

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