Hydrochloric Acid → Dimethylamino-(1,4-dioxaspiro[4.5]dec-8-yl)-acetonitrile

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Reaction Steps

40% aqueous dimethylamine solution (85 ml, 0.67 mole), 1,4-dioxa-spiro-[4.5]decane-8-carbaldehyde 11 (240 g, 0.141 mole) and potassium cyanide (22.05 g, 0.338 mole) were added dropwise to a mixture of 4N hydrochloric acid (37 ml) and methanol (22 ml) while cooling with ice. The mixture was stirred for 4 days at room temperature and was then extracted with diethyl ether (4×100 ml) after adding water (80 ml). The organic phase was dried over sodium sulfate, concentrated by evaporation in vacuo, and the product was obtained as a white solid.

Provenance & Evidence