Hydrochloric Acid → HCID 11553248, compound

Participants

Reaction Steps

1-[4-(Benzhydrylideneamino)benzyl]-6-(3,4,5-trimethoxyphenyl)-1,3-dihydroimidazo[4,5-b]pyrazin-2-one (10 mg, 0.0175 mmol) was dissolved in THF (0.5 mL) and 4N aq. HCl (0.3 mL) was added. The mixture was stirred overnight at room temperature, concentrated under reduced pressure, and the resultant residue was purified by silica gel chromatography [EtOAc] to afford 1-(4-aminobenzyl)-6-(3,4,5-trimethoxyphenyl)-1,3-dihydroimidazo[4,5-b]pyrazin-2-one (1.8 mg, 20% overall yield) as a yellow solid. 1H NMR (300 MHz, CDCl3): δ 8.90 (br, 1H), 8.32 (s, 1H), 7.40 (d, J=8.1 Hz, 2H), 7.19 (s, 2H), 6.62 (d, J=8.1 Hz, 2H), 5.08 (s, 2H), 3.99 (s, 6H), 3.92 (s, 3H). MS: 408.1 (M+H).

Provenance & Evidence