Aminopyrazine → HCID 21034118, compound

HRID 1821724Notes

Reaction equation

HRID 1821724 reaction equation
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]=[C:11]=[O:12].[NH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>C(COC)OC>[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]([NH:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1)=[O:12]

Participants

4

Reactant 2

HCID 78747AminopyrazineHCID 27333702-(Difluoromethoxy)phenyl isocyanate

Product 1

HCID 21034118HCID 21034118, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

2-(Difluoromethoxy)phenylisocyanate (1.0 g, 5.4 mmol) and aminopyrazine (0.51 g, 5.4 mmol) were reacted for 6 hours in refluxing dimethoxyethane (20 mL). The reaction mixture was cooled to room temperature to precipitate the product, which was collected by filtration, washed with ethyl acetate, and dried in vacuo (765 mg, 50%). 1H NMR (300 Mhz, d6-DMSO) δ: 10.49 (br s, 1H), 10.26 (s, 1H), 8.83 (s, 1H), 8.35-8.24 (m, 3H), 7.53-7.00 (m,4H).

Workup

  1. customto precipitate the product, which
  2. filtrationwas collected by filtration
  3. washwashed with ethyl acetate
  4. customdried in vacuo (765 mg, 50%)

Sources & evidence

ORD record
ord-504ef51e8c3b4503bb4f2f3d68a2d70a
Source dataset
uspto-grants-2009_10
Patent number
US07608618B2

Reaction notes

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