HCID 57893515, compound → HCID 57893557, compound

Participants

Reaction Steps

[5-(Dibenzylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl](phenyl)methanol (Example 54) was oxidized using manganese dioxide to provide [5-(dibenzylamino)-1 h-pyrrolo[2,3-c]pyridin-2-yl](phenyl)methanone following the procedure described for Example 139 using methylene chloride as a solvent. Trituration of the crude material with Et2O provided [5-(dibenzylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl](phenyl)methanone (220 mg, 44%) as a yellow solid: 1H NMR (300 MHz, CD3OD) δ4.77 (4H, s), 6.69 (1H, s), 6.82 (1H, s), 7.19-7.27 (10H, m), 7.53-7.65 (3H, m), 7.92-7.95 (2H, m), 8.57 (1H, s); ESI MS m/z 418 [C28H23N3O+H]+; HPLC (Method A) >99% (AUC), tR=20.9 min.

Provenance & Evidence