HCID 57893488, compound → HCID 57893525, compound

Participants

Reaction Steps

1-[5-(Dibenzylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl]ethanol (Example 53) was oxidized using manganese dioxide to provide 1-[5-(dibenzylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl]ethanone following the procedure described for Example 139 using tetrahydrofuran as a solvent. Purification by Biotage chromatography provided 1-[5-(dibenzylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl]ethanone (200 mg, 40%) as a yellow solid: 1H NMR (300 MHz, CD3OD) δ2.54 (3H, s), 4.76 (4H, s), 6.67 (1H, s), 6.97 (1H, s), 7.12-7.30 (10H, m), 8.50 (1H, s); ESI m/z 356 [C23H21N30+H]+; HPLC (Method A) >99% (AUC), tR=18.8 min.

Provenance & Evidence