Hydrochloric Acid → HCID 178465623, compound

Participants

Reaction Steps

A mixture of 1-[5-(dibenzylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl]ethanone (Example 56) (91 mg, 0.26 mmol), aminoguanidine hydrochloride (30 mg, 0.27 mmol) and 6 N HCl (0.22 mL) in ethanol (10 mL) was heated to reflux under a nitrogen atmosphere for 1.5 h. The reaction mixture was cooled to room temperature, and the desired product precipitated from the solution. The solid was collected by filtration and rinsed with ethanol. After drying, [[1-[5-(dibenzylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl]ethylidene]amino]guanidine dihydrochloride (82 mg, 65%) was obtained as a yellow solid: EST MS m/z 412 [C24H25N7+H]+; HPLC (Method A) 94.9% (AUC), tR=16.5 min.

Provenance & Evidence