Hydrochloric Acid → HCID 136366008, compound

Participants

Reaction Steps

Phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone O-(2-aminoethyl)oxime hydrochloride was prepared by treating tert-butyl 2-[[[phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methylene]amino]oxy]ethylcarbamate (Example 60) with ethereal hydrogen chloride as an off-white solid (a mixture of isomers): mp 176-184° C. dec.; 1H NMR (500 MHz, CD3OD) δ 3.22 (2H, br s), 3.37 (2H, br s), 4.44-4.81 (2H, m), 6.68 (0.17H, s) 7.00 (0.83H, s), 7.37-7.54 (6H, m), 7.97-8.20 (1H, m), 8.96 (0.17H, br s), 9.14 (0.83H, br s); ESI MS m/z 281 [C16H16N4O+H]+; HPLC (Method A) 98.3% (AUC), tR=13.0 and 13.2 min.

Provenance & Evidence