HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → 3-acetyl-1H-indole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | methyl 3-acetyl-1H-indole-5-carboxylate | HCID 11629897 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-acetyl-1H-indole-5-carboxylic acid | HCID 11557497 | — |
Reaction Steps
0.686 g (3.16 mmol) methyl-3-acetylindole-5-carboxylate are dissolved under heat in 10 ml tetrahydrofurane and 10 ml ethylene glycol and mixed with 7.08 g (0.13 mol) potassium hydroxide. Having stirred under reflux for 30 minutes, the reaction mixture is cooled to room temperature. The tetrahydrofurane is removed on the rotary evaporator and the solution is acidified under ice cooling with 20 ml 6N hydrochloric acid. The precipitated light violet precipitate is sucked off and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608633B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-ef564195514c4edba2003ec56fe940af |
| Source note | uspto-grants-2009_10 |