Trifluoroacetic acid → HCID 11532809, compound

Participants

Reaction Steps

50 mg (0.096 mmol) tert-butyl-1-[3-(4-decyloxyphenoxy)-2-oxopropyl]indole-5-carboxylate are dissolved in 15 ml absolute dichloromethane and mixed with 0.82 g (7.19 mmol) trifluoroacetic acid. Having stirred at room temperature for 4 hours, the batch is concentrated to dryness on the rotary evaporator. Three admixtures with 10 ml of a mixture of petroleum ether and ethyl acetate (4:1) each and respective concentration to dryness on the rotary evaporator leave as a crude product a solid which is purified on an RP-HPLC column by means of chromatography (stationary phase: cromasil, flow agent: acetonitrile/water 90:10).

Provenance & Evidence