5-Benzyloxy-1-heptylindole → HCID 68839366, compound

Participants

Reaction Steps

0.5 g (1.55 mmol) 5-benzyloxy-1-heptylindole is dissolved in a Schlenk flask in 10 ml methanol and 4 ml dichloromethane. 0.06 g Pd (10%)/C is added and the mixture is rinsed with nitrogen for 15 minutes. Thereafter, a balloon filled with hydrogen is placed on the Schlenk piston and hydrogenation is carried out at room temperature for 12 h. The batch is filtrated on a frit and the solvent is removed in vacuo. The residue is purified on silica gel by means of column chromatography (flow agent: hexane/ethyl acetate 9:1). The product accrues as an oil.

Provenance & Evidence