反应详情

温度

0 °C

Suspend lithium aluminum hydride (0.76 g, 20.0 mmol) in dry tetrahydrofuran (10 mL) and cool to 0° C. Add, dropwise with stirring, 1-benzyl-3-methyl-piperidin-4-one (4.06 g, 20.0 mmol) in tetrahydrofuran (20 mL). After 1 hr., quench with saturated potassium sodium tartrate solution. After 20 min., extract with ethyl acetate (2×100 mL), wash the combined organic layers with aqueous NaCl solution (100 mL), dry over sodium sulfate, filter, and concentrate to obtain the title compound (4.15 g, >100%). Mass spectrum (electrospray): m/z=206.1 (M+1).

1. additionAdd
2. custom, quench with saturated potassium sodium tartrate solution
3. waitAfter 20 min.
4. extractionextract with ethyl acetate (2×100 mL)
5. washwash the combined organic layers with aqueous NaCl solution (100 mL)
6. dry with materialdry over sodium sulfate
7. filtrationfilter
8. concentrationconcentrate