4-Fluorobenzoyl chloride → HCID 69067478, compound

Participants

Reaction Steps

Using a method similar to example 160, starting with 6-(1-methyl-piperidin-4-yloxy)-pyridin-2-ylamine (preparation 60, 150 mg, 0.724 mmol) and 4-fluorobenzoyl chloride (128 μL, 1.08 mmol) yields the title compound (256 mg, 97%). Mass spectrum (ion spray): m/z 330.1 (M+1); Analysis calculated for C18H21N3O2FCl.0.5H2O. The C, 57.68; H, 5.92; N, 11.21. Found: C, 57.76; H, 6.17; N, 11.44. mp=203-205° C.

Provenance & Evidence