2,4-Difluorobenzoyl chloride → HCID 69074371, compound

Participants

Reaction Steps

Using a method similar to example 160, using 6-(1-methyl-piperidin-4-yloxy)-pyridin-2-ylamine (preparation 60, 150 mg, 0.724 mmol) and 2,4-difluorobenzoyl chloride (133 μL, 1.08 mmol) yields the title compound (230 mg, 83%). Mass spectrum (ion spray): m/z 348.1 (M+1); Analysis calculated for C18H20N3O2ClF2.0.5H2O. Theory: C, 55.03; H, 5.39; N, 10.70. Found: C, 54.88; H, 5.39; N, 10.73. mp=269-271° C.

Provenance & Evidence