反应详情

At first, a mixture of the 4-(diallylethoxysilyl)iodobenzene (187 mg, 0.52 mmol) obtained in Example 2, Pd(PPh3)4 (18.1 mg, 0.016 mmol), K2CO3 (108 mg, 0.78 mmol), and 4-methoxyphenyl boronic acid (95.2 mg, 0.63 mmol) was added with dist.toluene (5 mL). Subsequently, the resultant mixture was stirred under a nitrogen atmosphere at 80° C. for 13 hours to obtain a reaction mixture. Thereafter, a salt formed in the reaction mixture was removed by filtering with celite. The solvent was distilled from the organic layer with an evaporator to obtain a crude product. After that, the crude product thus obtained was separated and purified by silica gel column chromatography (hexane/EtOAc=10/1), and thereby 4-(diallylethoxysilyl)-4′-methoxybiphenyl was obtained (157.3 mg, 89% yield).

1. additionwas added with dist
2. customto obtain a reaction mixture
3. customThereafter, a salt formed in the reaction mixture
4. customwas removed
5. filtrationby filtering with celite
6. distillationThe solvent was distilled from the organic layer with an evaporator
7. customto obtain a crude product
8. customAfter that, the crude product thus obtained
9. customwas separated
10. custompurified by silica gel column chromatography (hexane/EtOAc=10/1)