反应详情

At first, a mixture of the 4-(diallylethoxysilyl)bromobenzene (191 mg, 0.61 mmol) obtained in Example 1, Pd(PPh3)4 (21.3 mg, 0.018 mmol), K2CO3 (127 mg, 0.92 mmol), and 4-methoxyphenyl boronic acid (112 mg, 0.74 mmol) was added with dist.toluene (5 mL). Subsequently, the resultant mixture was stirred under a nitrogen atmosphere at 80° C. for 13 hours to obtain a reaction mixture. Thereafter, a salt formed in the reaction mixture was removed by filtering with celite. The solvent was distilled from the organic layer with an evaporator to obtain a crude product. After that, the crude product thus obtained was separated and purified with PTLC (hexane/EtOAc=10/1), and thereby 4-(diallylethoxysilyl)-4′-methoxybiphenyl was obtained (125.4 mg, 60% yield).

1. additionwas added with dist
2. customto obtain a reaction mixture
3. customThereafter, a salt formed in the reaction mixture
4. customwas removed
5. filtrationby filtering with celite
6. distillationThe solvent was distilled from the organic layer with an evaporator
7. customto obtain a crude product
8. customAfter that, the crude product thus obtained
9. customwas separated
10. custompurified with PTLC (hexane/EtOAc=10/1)