Potassium Carbonate → HCID 57894272, compound

Participants

Reaction Steps

A mixture of the 4-(diallylhydroxysilyl)iodobenzene (151 mg, 0.46 mmol) obtained in Example 17, Pd(PPh3)4 (15.9 mg, 0.014 mmol), K2CO3 (94.8 mg, 0.69 mmol), and 4-methoxyphenyl boronic acid (83.4 mg, 0.55 mmol) was added with dist.toluene (5 mL). Subsequently, the resultant mixture was stirred under a nitrogen atmosphere at 80° C. for 38 hours to obtain a reaction mixture. Thereafter, a salt formed in the reaction mixture was removed by filtering with celite. The solvent was distilled from the organic layer with an evaporator to obtain a crude product. After that, the crude product thus obtained was separated and purified by silica gel column chromatography (hexane/EtOAc=3/1), and thereby 4-(diallylhydroxysilyl)-4′-methoxybiphenyl was obtained (76.1 mg, 54% yield).

Provenance & Evidence