2-Cyclohexen-1-one → 3-(Di(iso-butyl)phosphino)cyclohexan-1-one

HRID 1822102노트

반응식

HRID 1822102 반응식
[C:1]1(=[O:7])[CH2:6][CH2:5][CH2:4][CH:3]=[CH:2]1.[CH2:8]([PH:12][CH2:13][CH:14]([CH3:16])[CH3:15])[CH:9]([CH3:11])[CH3:10]>>[CH2:8]([P:12]([CH2:13][CH:14]([CH3:16])[CH3:15])[CH:3]1[CH2:4][CH2:5][CH2:6][C:1](=[O:7])[CH2:2]1)[CH:9]([CH3:11])[CH3:10]

참가 물질

3

반응물 2

HCID 135942-Cyclohexen-1-oneHCID 77622Phosphine, bis(2-methylpropyl)-

생성물 1

HCID 689810273-(Di(iso-butyl)phosphino)cyclohexan-1-one

반응 조건

온도
45 °C

실험 절차

A 250 ml round-bottomed flask fitted with a condenser, nitrogen purge, and addition funnel was charged with 29.9 g (0.3 mol) 2-cyclohexen-1-one and heated to 45° C. with stirring. Di-(iso-butyl)phosphine (28.8 g, 0.2 mol) was gradually added to the flask via the addition funnel, over a period of 0.5 hour. When addition was complete, the temperature of the contents of the flask was slowly raised to 70° C. and maintained at that temperature for 3 hours, then cooled. Unreacted starting materials were removed by evaporation under reduced pressure at 120° C.

후처리

  1. customA 250 ml round-bottomed flask fitted with a condenser
  2. customnitrogen purge
  3. additionaddition funnel
  4. additionWhen addition
  5. temperaturethe temperature of the contents of the flask was slowly raised to 70° C.
  6. temperaturemaintained at that temperature for 3 hours
  7. temperaturecooled
  8. customwere removed by evaporation under reduced pressure at 120° C.

출처 및 근거

ORD 기록
ord-9aafed3bd2884dd281a16a76632b66ca
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07608713B2

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