Methanol → HCID 178485221, compound

HRID 1822122Notes

Reaction equation

HRID 1822122 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:11][N:10]([C:19]([NH:30][CH3:31])=[N:20][S:21]([N:24]3[CH2:29][CH2:28]O[CH2:26][CH2:25]3)(=[O:23])=[O:22])[N:9]=2)=[CH:4][CH:3]=1.[CH3:32]O>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:11][N:10]([C:19]([NH:30][CH3:31])=[N:20][S:21]([N:24]3[CH2:29][CH2:28][CH2:32][CH2:26][CH2:25]3)(=[O:23])=[O:22])[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 178485223HCID 178485223, compound

Product 1

HCID 178485221HCID 178485221, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(−)-(4S)-3-(4-Chlorophenyl)-N-methyl-N′-((morpholin-4-yl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine. ([α25D]=−144°, c=0.01, MeOH). (Chiral stationary phase: Chiralpak AD). The mobile phase consisted of ethanol. Amorphous.

Sources & evidence

ORD record
ord-2d1dd85fdf154999b98cda59d4bcdbf1
Source dataset
uspto-grants-2009_10
Patent number
US07608718B2

Reaction notes

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