Potassium oxalate monohydrate → cis-oxalato-trans-l-1,2-diaminocyclohexaneplatinum(II)

Participants

Reaction Steps

Cis-dichloro compound was consumed in 4-5 h and the cis-diacetato compound was formed in 85-95% (by HPLC). The reaction mixture was filtered through celite 2-3 times to get a clear filtrate. Water was recovered at 50° C. under reduced pressure to give cis-diacetato-trans-l-diaminocyclohexane platinum(II) as a white solid (21 g, 83%). The above solid (21 g, 0.049 mol) was again dissolved in water 2.1 liters and heated with dipotassium oxalate monohydrate, 8.11 g (0.044 mol) at 60-70° C. for 5-6 h. Workup of the reaction as in example-5 produced 17.5 g of oxaliplatin (67%).

Provenance & Evidence