HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → n-Benzyl-n-(3-chloro-4-fluorophenyl)alanine lithium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | methyl N-benzyl-N-(3-chloro-4-fluorophenyl)alaninate | HCID 68982233 | — |
| Solvent | Water | HCID 962 | — |
| Product | n-Benzyl-n-(3-chloro-4-fluorophenyl)alanine lithium salt | HCID 68981703 | — |
Reaction Steps
Methyl N-benzyl-N-(3-chloro-4-fluorophenyl)alaninate (2-1, 0.870 g, 2.704 mmol) in a 3:1:1 mixture of THF:MeOH:H2O (100 mL) was treated with LiOH hydrate (0.119 g, 2.974 mmol) then stirred 24 h. Upon completion, the reaction mixture was concentrated under vacuum to yield N-benzyl-N-(3-chloro-4-fluorophenyl)alanine lithium salt (2-2). MS 308.2 found, 308.7 (M+H+) required.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608739B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-9de40df84bc341899073b0184ef57dbf |
| Source note | uspto-grants-2009_10 |