Water → HCID 178524348, compound

Participants

Reaction Steps

To a solution of 3-[2-(4-cyanophenyl)ethyl]-5-phenyl-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (100 mg, 0.26 mmol, prepared in Example 12) in DMSO (2 ml) was added 50% sulfuric acid (2 ml) and the mixture was heated under reflux for 2 hours. To the resultant reaction mixture was added water, and precipitates were filtered off, and dried to give 3-[2-(4-carboxyphenyl)ethyl]-5-phenyl-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (107 mg, quantitative yield).

Provenance & Evidence