Dimethylformamide → HCID 178489437, compound

Participants

Reaction Steps

To a suspension of 4-hydroxy-3-[1-oxo-2-(2-methoxyphenyl)ethyl]-1-phenyl-1,8-naphthyridin-2 (1H)-one (121 mg, 0.31 mmol, prepared in Synthetic Example 16) in DMF (3 ml) was added hydrazine monohydrate (80%, 50 μl, 1.25 mmol, 4.0 eq.), and the mixture was treated in the same manner as in Example 16 to give 3-(2-methoxybenzyl)-5-phenyl-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (111 mg, 93%).

Provenance & Evidence