Water → HCID 178524349, compound

Participants

Reaction Steps

To a solution of 3-[2-(3-cyanophenyl)ethyl]-5-phenyl-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (300 mg, 0.77 mmol, prepared in Example 18) in DMSO (30 ml) was added 50% sulfuric acid (15 ml), and the mixture was heated under reflux overnight. The reaction mixture was admixed with water, and filtered to give precipitates which were dried to afford 3-[2-(3-carboxyphenyl)ethyl]-5-phenyl-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (87 mg, 28%).

Provenance & Evidence