Water → HCID 178524376, compound

Participants

Reaction Steps

To a solution of 3-benzyl-5-(3-cyanophenyl)-1H-pyrazolo [4,3-c][1,8]naphthyridin-4 (5H)-one (120 mg, 0.32 mmol, prepared in Example 53) in DMSO (15 ml) was added 50% sulfuric acid (5 ml), and the mixture was heated under reflux for 2.5 hours. The reaction mixture was admixed with water, and filtered to give precipitates which were dried to afford 3-benzyl-5-(3-carboxyphenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (73 mg, 58%).

Provenance & Evidence