Water → HCID 178515061, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-hydroxy-3-(1-oxo-4-phenylbutyl)-1-phenyl-1,8-naphthyridin-2 (1H)-one (384 mg, 11.0 mmol, prepared in Synthetic Example 30) in DMF (4 ml) was added hydrazine monohydrate (80%, 160 μl, 4.0 mmol, 4.0 eq.), and the mixture was stirred at 100 to 110° C. for 2 hours. The reaction mixture was admixed with water, and filtered to give precipitates which were washed with water and dried to afford 5-phenyl-3-(3-phenylpropyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (354 mg, 93%).

Provenance & Evidence