4-Chloro-2-phenoxyphenol → 3-{4-[2-(4-Chloro-2-phenoxy-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid

HRID 1822277Notes

Reaction equation

HRID 1822277 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2Br)=[CH:8][C:7]=1[CH3:20].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:24]=1>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:21])=[C:7]([CH3:20])[CH:8]=2)=[C:25]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 127742954-Chloro-2-phenoxyphenolHCID 578942223-[4-(2-Bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester

Product 1

HCID 578941893-{4-[2-(4-Chloro-2-phenoxy-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid

Procedure

The title compound is prepared by reacting the compound of 3-[4-(2-bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 4-chloro-2-phenoxy-phenol as in Example 18 to afford 0.039 g (8%). 1H NMR (400 MHz, CDCl3); MS (ES−) m/z mass calculated for C28H23O5Cl 474, found 473 and 475 (M−1, and M+1).

Workup

  1. customto afford 0.039 g (8%)

Sources & evidence

ORD record
ord-e5741d0542d54341b9fd945ed7f40420
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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