4-(Methanesulfonyl)phenylboronic acid → HCID 11478791, compound

HRID 1822292Notes

Reaction equation

HRID 1822292 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[CH3:35][S:36]([C:39]1[CH:44]=[CH:43][C:42](B(O)O)=[CH:41][CH:40]=1)(=[O:38])=[O:37]>>[CH3:35][S:36]([C:39]1[CH:44]=[CH:43][C:42]([C:27]2[CH:26]=[C:25]([C:28]([F:30])([F:31])[F:29])[CH:24]=[CH:23][C:22]=2[O:21][C:16]2[CH:15]=[C:14]([CH:19]=[C:18]([CH3:20])[CH:17]=2)[O:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:34])=[O:3])=[C:8]([CH3:33])[CH:9]=2)=[CH:41][CH:40]=1)(=[O:38])=[O:37]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 57894173HCID 57894173, compound

Product 1

HCID 11478791HCID 11478791, compound

Procedure

The title compound is prepared by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with 4-(methylsulfonyl)phenyl boronic acid as in Example 38 to afford 0.062 g (48%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C31H27O6SF3 584, found 585 (M+1, 100%).

Workup

  1. customto afford 0.062 g (48%)

Sources & evidence

ORD record
ord-6f9d8f5525fa47a5bac1042624e9e52d
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

Loading…