2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 11490223, compound

HRID 1822293Notes

Reaction equation

HRID 1822293 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[F:35][C:36]([F:48])([F:47])[O:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1B(O)O>>[CH3:33][C:8]1[CH:9]=[C:10]([O:13][C:14]2[CH:15]=[C:16]([O:21][C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:30])([F:31])[F:29])=[CH:26][C:27]=3[C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=3[O:37][C:36]([F:48])([F:47])[F:35])[CH:17]=[C:18]([CH3:20])[CH:19]=2)[CH:11]=[CH:12][C:7]=1[CH2:6][CH2:5][C:4]([OH:34])=[O:3]

Participants

3

Reactant 2

HCID 27772042-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 57894173HCID 57894173, compound

Product 1

HCID 11490223HCID 11490223, compound

Procedure

The title compound is prepared by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with 2-trifluoromethoxyphenyl boronic acid as in Example 38 to afford 0.058 g (39%). 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C31H25O5F6 591.1606, found 591.1619.

Workup

  1. customto afford 0.058 g (39%)

Sources & evidence

ORD record
ord-fdc56cdcd8804161a35303b586f92419
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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