3-Acetylphenylboronic acid → HCID 57894210, compound

HRID 1822311Notes

Reaction equation

HRID 1822311 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[C:35]([C:38]1[CH:39]=[C:40](B(O)O)[CH:41]=[CH:42][CH:43]=1)(=[O:37])[CH3:36]>>[C:35]([C:38]1[CH:43]=[C:42]([C:23]2[CH:24]=[C:25]([C:28]([F:31])([F:30])[F:29])[CH:26]=[CH:27][C:22]=2[O:21][C:16]2[CH:15]=[C:14]([CH:19]=[C:18]([CH3:20])[CH:17]=2)[O:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:3])=[O:34])=[C:8]([CH3:33])[CH:9]=2)[CH:41]=[CH:40][CH:39]=1)(=[O:37])[CH3:36]

Participants

3

Reactant 2

HCID 27343103-Acetylphenylboronic acidHCID 57894173HCID 57894173, compound

Product 1

HCID 57894210HCID 57894210, compoundYield 72%

Procedure

The compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester is reacted with 3-acetyl phenyl boronic acid as in Example 38 to afford 0.186 g (72%) of the title compound. 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C32H28O5F3 549.1888, found 549.1880.

Sources & evidence

ORD record
ord-308aef60d49e4341a9b876bb93b11e3d
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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