3-Fluorophenol → HCID 57894152, compound

HRID 1822313Notes

Reaction equation

HRID 1822313 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[F:35][C:36]1[CH:37]=[C:38]([OH:42])[CH:39]=[CH:40][CH:41]=1>>[F:35][C:36]1[CH:37]=[C:38]([CH:39]=[CH:40][CH:41]=1)[O:42][C:23]1[CH:24]=[C:25]([C:28]([F:29])([F:30])[F:31])[CH:26]=[CH:27][C:22]=1[O:21][C:16]1[CH:15]=[C:14]([CH:19]=[C:18]([CH3:20])[CH:17]=1)[O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:34])=[O:3])=[C:8]([CH3:33])[CH:9]=1

Participants

3

Reactant 2

HCID 97433-FluorophenolHCID 57894173HCID 57894173, compound

Product 1

HCID 57894152HCID 57894152, compoundYield 40%

Procedure

The compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester is reacted with 3-fluorophenol as in Example 45 to afford 0.106 g (40%) of the title compound. 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z mass calculated for C30H25O5F4 541.1638, found 541.1625.

Sources & evidence

ORD record
ord-cea23570128d46cb8478b918a976e422
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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