HCID 69073335, compound → HCID 57894203, compound

Participants

Reaction Steps

A mixture of 3-{2-ethyl-4-[3-methyl-5-(2-o-tolyloxy-4-trifluoromethyl-phenoxy)phenoxy]-phenyl}-acrylic acid ethyl ester (1.83 g, 3.17 mmol) and 10% Pd/C (1.80 g) in ethyl acetate (100 mL) is purged with N2 then H2 and then stirred under a H2 balloon at rt for 5 hours. The mixture is filtered through hyflo, and the solvent is removed in vacuo to afford 1.77 g (97%) of the title compound. Rf=0.22 (9/1 hexanes/EtOAc). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C34H33F3O5 578, found 579 (M+1, 100%).

Provenance & Evidence