HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(4-Hydroxy-2-methylphenyl)propanoate → 3-[4-(3-Bromo-5-ethyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(4-Hydroxy-2-methylphenyl)propanoate | HCID 13551833 | — |
| Reactant | 3,5-Dibromoethylbenzene | HCID 18711807 | — |
| Product | 3-[4-(3-Bromo-5-ethyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester | HCID 57894146 | 56% |
Reaction Steps
Compound of 1,3-dibromo-5-ethyl-benzene is reacted with 3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester as in Example 18 to afford 0.898 g (56%) of the title compound. Rf=0.32 (4/1 hexanes/EtOAc). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C19H21O3Br 376, found 377 and 379 (M+1 and M+3, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608639B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-a04c183c065641e1894daba96423362a |
| Source note | uspto-grants-2009_10 |